High-fat diet-activated fatty acid oxidation mediates intestinal stemness an tumorigenicity. Cell Reports. (2021) Jun 8;Vol.35, Issue10. PMID:34107251
Mana MD*, Hussey AM, Tzouanas CN, Imada S, Barrera Millan Y, Bahceci D, Saiz DR, Webb AT, Lewis CA, Carmeliet P, Mihaylova MM, Shalek AK, and Yilmaz ÖH*.
* Co-corresponding
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. (2016) Mar 3;531(7592): 53-58. PMID:26935695
Beyaz S*, Mana MD*, Roper J*, Kedrin D, Saadatpour A, Hong S-J, Bauer-Rowe KE, Xifaras ME, Akkad A, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Lamming D, Dogum R, Guo G, Selig M, Nielsen GP, Gupta N, Ferrone C, Deshpande V, Yuan G-C, Orkin SH, Sabatini DM, and Yilmaz ÖH.
* equal contribution
Gut organoids: mini-tissues in culture to study intestinal physiology and disease. Am J Physiol Cell Physiol. 2019 Sep 1;317(3):C405-C419. PMID:31216420
Almeqdadi M, Mana MD, Roper J,Yilmaz ÖH
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. Nature (2019) Jul;571(7765):398-402. PMID: 31292548
Pentinmikko N, Iqbal S, Mana M, Andersson S, Cognetta AB 3rd, Suciu RM, Roper J, Luopajärvi K, Markelin E, Gopalakrishnan S, Smolander OP, Naranjo S, Saarinen T, Juuti A, Pietiläinen K, Auvinen P, Ristimäki A, Gupta N, Tammela T, Jacks T, Sabatini DM, Cravatt BF, Yilmaz ÖH, Katajisto P
Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions. Clin Cancer Res (2019). PMID: 31852835.
Rickelt S, Condon C, Mana M, Whittaker C, Pfirschke C, Roper J, Patil DT, Brown I, Mattia AR, Zukerberg L, Zhao Q, Chetty R, Lauwers GY, Neyaz A, Leijssen LGJ, Boylan K, Yilmaz OH, Deshpande V, Hynes RO.
High-fat diet in a mouse insulin-resistant model induces widespread rewiring of the phosphotyrosine signaling network. Mol Syst Biol. 2019 Aug;15(8):e8849. PMID:31464373.
Dittmann A, Kennedy NJ, Soltero NL, Morshed N,Mana MD, Yilmaz ÖH, Davis RJ, White FM.
Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. Cell Stem Cell. (2018) 22, issue 5, 769-778. PMID:29727683
Maria M. Mihaylova*, Chia-Wei Cheng*, Amanda Q. Cao^, Surya Tripathi^, Miyeko D. Mana, Khristian E. Bauer-Rowe, Monther Abu-Remaileh, Laura Clavain, Aysegul Erdemir, Caroline A. Lewis, Elizaveta Freinkman, Audrey S. Dickey, Albert R. La Spada, Yanmei Huang, George W. Bell, Vikram Deshpande, Peter Carmeliet, Pekka Katajisto, David Sabatini, Omer Yilmaz
*^equal contribution
Dietary Regulation of Adult Stem Cells. Curr Stem Cell Rep. (2017) Mar 3(1):1-8. PMID:28966904
Mana MD*, Kuo EY*, Yilmaz ÖH. *equal contribution
Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells Cell Stem Cell. 2017 June, v20; 6: 801-816. PMID: 28285904.
Barriga M, Montagni E, Mana M, Mendez-Lago M, Hernando-Momblona X, Sevillano M, Guillaument-Adkins A, Rodriguez-Esteban G, Buczacki SJA, Gut M, Heyn H, Winton DJ, Yilmaz OH, Attolini CS-O, Gut I, Batlle E.
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Cell Stem Cell. 2016 Aug 4;19(2):205-216. PMID: 27184401.
Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio IIC, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW.